[Sebastian Falk]

Dear all!

We got reviewer comments on our SEC MALS data concerning the monodispersity of the sample.

When the polydispersity index Mw/Mn equals 1.000, then the sample is monodisperse.
We measure Mw/Mn between 1.000 for our best sample and 1.006 – 1.009 for our worst protein samples. Are there any thresholds in the literature one could refer to?

The experimentally determined mass fits the theoretical mass well, but we would like to make our arguments stronger by including the Mw/Mn ratio. I would appreciate any feedback.

Thank you! best
Sebastian

[Mario Lebendiker]

Dear Sebastian
Although we are doing many times SEC or IEX MALS, I never use “”polydispersity index Mw/Mn””, and never was asked for it…
I would consult the people of WYATT. They are very friendly and help us a lot .
In my case I use to consult Dan Somme for all my troubles.
If you do it, let us know his answer
Best,
Mario

[Author]

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